|Research & Discoveries|
Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study
Kevin J. Ruff & Anne Winkler & Robert W. Jackson & Dale P. DeVore & Barry W. Ritz
"Abstract Natural Eggshell Mspan style="font-style:italic;"brane (NEM®) is a new novel dietary supplspan style="font-style:italic;"ent that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium. The randomized, multicenter, double-blind, placebo-controlled Osteoarthritis Pain Treatment Incorporating NEM® clinical study was conducted to evaluate the efficacy and safety of NEM® as a treatment for pain and stiffness associated with osteoarthritis of the knee. Sixty-seven patients were randomly assigned to receive either oral NEM® 500 mg (n=34) or placebo (n=33) daily for 8 weeks. The primary endpoint was the change in overall Western Ontario and McMasters Universities (WOMAC) Osteoarthritis Index as well as pain, stiffness, and function WOMAC subscales measured at 10, 30, and 60 days. The clinical assessment was performed on the intent-to-treat population. Supplspan style="font-style:italic;"entation with NEM®
Natural Eggshell Mspan style="font-style:italic;"brane (NEM®) is an effective and safe option for the treatment of pain and stiffness associated with knee osteoarthritis. Supplspan style="font-style:italic;"entation with NEM®, 500 mg taken once daily, significantly reduced both joint pain and stiffness compared to placebo at 10, 30, and 60 days. The Clinical Trial Registration number for this study is NCT00750477."