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Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion

Kathleen F. Benson,1 Kevin J. Ruff,2 and Gitte S. Jensen

Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion

Kathleen F. Benson,1 Kevin J. Ruff,2 and Gitte S. Jensen

"ABSTRACT Tumor necrosis factor-a (TNF-a) plays an important role in inflammatory processes. This study examined the effects of natural eggshell membrane (NEM) (ESM Technologies, LLC, Carthage, MO, USA) on interleukin (IL)-2,...

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Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy

Kevin J Ruff1 Paul L Durham2 A ustin O’Reilly2 F Daniel Long1

Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy

Kevin J Ruff1 Paul L Durham2 A ustin O’Reilly2 F Daniel Long1

"Purpose: Eggshell membrane (ESM) has been shown to contain naturally occurring bioactive components, and biological activities such as reducing proinflammatory cytokines, liver fibrosis, and joint pain in osteoarthritis sufferers...

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Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Kevin J. Ruff & Anne Winkler & Robert W. Jackson & Dale P. DeVore & Barry W. Ritz

Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Kevin J. Ruff & Anne Winkler & Robert W. Jackson & Dale P. DeVore & Barry W. Ritz

"Abstract Natural Eggshell Membrane (NEM®) is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium....

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Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies

Kevin J Ruff1 Dale P DeVore2 Michael D Leu3 Mark A Robinson4

Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies

Kevin J Ruff1 Dale P DeVore2 Michael D Leu3 Mark A Robinson4

"Background: Natural Eggshell Membrane (NEM®) is a novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joint and connective tissues. Two single center,...

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NEM® Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis

Results From A Six Center, Open Label German Clinical Study

NEM® Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis

Results From A Six Center, Open Label German Clinical Study

"Abstract

Introduction NEM® brand eggshell membrane is a novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joint and connective...

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Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product

Kevin J. Ruff1*, Dale P. DeVore2

Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product

Kevin J. Ruff1*, Dale P. DeVore2

"ABSTRACT

NEM® brand eggshell membrane is a novel dietary supplement that has been clinically shown to alleviate arthritis joint pain and stiffness; however the mechanism of action is not well understood. Preliminary...

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